Development of the Nervous System
Generation of Sensory Hair Cells from Stem Cells
The loss of sensory hair cells from the ears of mammals is irreversible; hair cells are not regenerated and the resultant deafness is permanent. Many groups have contemplated stem cell therapy as an approach to solving this biomedical problem. Hair cells are also hard to come by; finding large numbers of cells for drug screening programs is, for example, problematic. Taking cues from what is known about how the ear forms during development, methods have been devised for generating sensory hair cells from stems cells. In this assessment you should compare and contrast the methods used, and evaluate the potential benefits/drawbacks of each system.
1. Oshima K, Shin K, Dienstuber M, Peng AW, Ricci AJ, Heller S (2010) Mechanosensitive hair-cell like cells from embryonic and induced pluripotent stem cells. Cell 141:704-716
2. Koehler KR, Mikosz, Molosh AI, Patel D, Hashino E (2013) Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature 500:217-221.
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